You Will Not Drop Body Fat If You’re Inflamed.

Body fat is a critical endocrine organ that governs our health and immunity!

❌Body fat is not just stored energy.
❌Losing body fat is not as simple as restricting calories.
❌Each time we lose body fat, it becomes more difficult to do it again the next time.

Here is the new paradigm to understanding body fat:

⚡️Body fat is a massive endocrine organ.
🦠It governs our health and immunity.
👴🏼Body fat is a critical inflammatory and aging mediator.
🩸Body fat regulates angiotensin; the formation of new blood vessels.
🔥It controls hormones like Leptin, which control our food intake.

The research shows “Leptin resistance” in those with obesity. Body fat is actively secreting leptin which causes these individuals to stop responding to it all-together. This makes people eat more.
Inflamed body fat will secrete the hormone adiponectin. Too much adiponectin will lead to insulin resistance.

Body fat is a multi-component system! It is not just “stored energy.”
There are many factors that may impact our body’s ability to drop body fat including;

If you have gained and lost weight repeatedly before in the past. This hardens the protective layer surrounding our fat cells, called; The ECM.

Caloric restriction, fasting, keto, etc. will work well in the short term but will fail to stand the test of time. You will not drop the body fat if it’s inflamed.

Those with poor gut health, immune issues and obesity will have excess M1 macrophages in their adipose tissue.
We need to steer these macrophages out of our fat mass or else it’ll be nearly impossible to drop the weight.
An obese fat cell is characterized by high populations of M1 macrophages.

Obesity = Inflammation.
Inflammation = M1 macrophages.

Obesity challenges macrophages to become active in the M1 state.
M1 Macrophages will then translocate into your fat mass (adipose tissue) which makes it extremely difficult to lose.
When macrophages translocate into your fat mass, they release inflammatory signal cascades of IL-1B, TNFa, and IL-6 in large amounts.

These inflammatory signals work to directly impair insulin and leptin, causing both insulin and leptin resistance.

Fat cells in Obesity actually take on the classic disease signature like cancer:

High Glucose consumption
Shift to Glycolysis
High ROS output
Low oxygen consumption
Inflammatory Cascade

A healthy cell, should mainly utilize oxphos (oxidative phosphorylation). This is the M2 state, when a cell can switch back and forth from glycolysis to oxphos without issues.

So why can’t caloric restriction work well in those with obesity?

You have large populations of M1 Macrophages in your adipose tissue that are driving inflammatory cytokines, leptin and insulin resistance!
The metabolic state of your fat cells are skewed by these macrophage populations.

Calories have nothing to do with this.

This is why we see time and time again, those struggling with obesity can drop their caloric intake to 1000 calories a day and still see no drop in weight.
The answer to this frustrating issue comes by targeting the gut first and steering macrophages to become anti-inflammatory (the M2 state).

Fat cells and Macrophage polarities are at the centre of immunity, as we can see how body fat is a very complex system. If we are forcing fat off of our body’s and not compensating for these rapid changes, we will in-turn regain the weight and create further inflammation in the future. It is important we first work to bring down inflammation in the gut to drop body fat and keep it off.

A quick and easy hack:

2 grams of HMO + 1 Scoop of Reds + Apple Peel Powder. This will help close and seal the gut and bring down the toxin LPS (lipopolysaccharide).
3-5 grams of D-Mannose in a fasted state upon waking. This will help shift macrophage populations in adipose tissue to the M2 state, making them anti-inflammatory and clearing away all the excess junk.